Interdisciplinary Review of General, Forensic, Prison and Military Psychiatry and Psychology and the related subjects of Behavior and Law with the occasional notes and comments by Michael Novakhov, M.D. (Mike Nova).
Sunday, June 16, 2013
Gray matter abnormalities in patients with narcissistic personality disorder
Publication date: Available online 15 June 2013 Source:Journal of Psychiatric Research Author(s): Lars Schulze , Isabel Dziobek , Aline Vater , Hauke R. Heekeren , Malek Bajbouj , Babette Renneberg , Isabella Heuser , Stefan Roepke Background Despite the relevance of narcissistic personality disorder (NPD) in clinical settings, there is currently no empirical data available regarding the neurobiological correlates of NPD. In the present study, we performed a voxel-based morphometric analysis to provide initial insight into local abnormalities of gray matter (GM) volume. Methods Structural brain images were obtained from patients with NPD (n = 17) and a sample of healthy controls (n = 17) matched regarding age, gender, handedness, and intelligence. Groups were compared with regard to global brain tissue volumes and local abnormalities of GM volume. Regions-of-interest analyses were calculated for the anterior insula. Results Relative to the control group, NPD patients had smaller GM volume in the left anterior insula. Independent of group, GM volume in the left anterior insula was positively related to self-reported emotional empathy. Complementary whole-brain analyses yielded smaller GM volume in fronto-paralimbic brain regions comprising the rostral and median cingulate cortex as well as dorsolateral and medial parts of the prefrontal cortex. Conclusion Here we provide the first empirical evidence for structural abnormalities in fronto-paralimbic brain regions of patients with NPD. The results are discussed in the context of NPD patients' restricted ability for emotional empathy.
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SAN FRANCISCO — Girls with anorexia nervosa experienced significant improvements in anxiety symptoms after estrogen replacement therapy, according to data presented here. “[Anorexia nervosa] is a condition that can be very difficult to treat,” study researcher Madhusmita Misra, MD, MPH, pediatric endocrinologist and associate professor of pediatrics at Massachusetts General Hospital and Harvard Medical School in Boston, said during a press conference at ENDO 2013. “Anxiety is commonly seen with anorexia nervosa, and increasing anxiety and body dissatisfaction with increasing weight during recovery can impede the chances of successful recovery.”
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For the past 15 years, I’ve helped raise a thoughtful, spirited young woman who is not my biological or adopted daughter. So, am I a “real” father? I’ve wrestled with that question, and Father’s Day always brings it into sharp relief.