Cognitive neuropsychiatric aspects of Delusional Disorder "are poorly understood" | Cognitive neuropsychiatry is a new field of cognitive psychologyThe neuropsychology of DDs is poorly understood |
Cognitive neuropsychiatry is a new field of cognitive psychology
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Neuropsychological aspects of delusional disorder.
Abdel-Hamid M, Brüne
M
Curr Psychiatry Rep. 2008 Jun;10(3):229-34
Authors: Abdel-Hamid M, Brüne M
Abstract
Delusional disorders (DDs) are clinically rare syndromes characterized by false beliefs that are held with firm conviction despite counterevidence. The neuropsychology of DDs is poorly understood. Two partially opposing models--a cognitive bias model and a cognitive deficit model--have received mixed empiric support, partly because most research has been carried out in patients with paranoid schizophrenia, with which the nosologic association of DDs is unknown. Based on these models, we review empiric findings concerning the neuropsychology of DDs (narrowly defined). We conclude that DDs can best be seen as extreme variations of cognitive mechanisms involved in rapid threat detection and defensive harm avoidance. From this viewpoint, the two models seem to be complementary in explanatory power rather than contradictory. Future research may help to clarify the question of gene-environment interaction involvement in the formation of delusional beliefs.
PMID: 18652791 [PubMed - indexed for MEDLINE]
Cognitive neuropsychiatry and delusional belief.
Coltheart M
Cognitive neuropsychiatry and delusional belief.
Q J Exp Psychol (Hove). 2007 Aug;60(8):1041-62
Authors: Coltheart M
Abstract
Cognitive neuropsychiatry is a new field of cognitive psychology
which seeks to learn more about the normal operation of high-level aspects of
cognition such as belief formation, reasoning, decision making, theory of mind,
and pragmatics by studying people in whom such processes are abnormal. So far,
the high-level cognitive process most widely studied in cognitive
neuropsychiatry has been belief formation, investigated by examining people with
delusional beliefs. This paper describes some of the forms of delusional belief
that have been examined from this perspective and offers a general two-deficit
cognitive-neuropsychiatric account of delusional belief.
PMID: 17654390 [PubMed - indexed for MEDLINE]
May 01 (15)
Tuesday, May 1, 2012
"Delusions are... now conceptualized as dimensional entities rather than categorical ones, lying at the extreme end of a "belief continuum"... A truly comprehensive model of the persecutory delusion requires further elucidation at the neurochemical and genetic levels." - PsychiatryOnline | American Journal of Psychiatry | Cognitive Neuropsychiatric Models of Persecutory Delusions
"Delusions are... now conceptualized as
dimensional entities rather than categorical ones, lying at the extreme end of a
"belief continuum"...
A truly comprehensive model of the persecutory delusion requires further elucidation at the neurochemical and genetic levels.
Finally, genetic studies, in the absence of a definitively linked genomic region of, for example, schizophrenia R1584BABBEHIC, currently are being designed to reduce genetic heterogeneity at the entry point of proband ascertainment. Thus, dimensional variables (e.g., delusional ideation, social cognitive skills) or symptom clusters (e.g., reality distortion) become intermediate phenotypes worthy of study (for preliminary examples of this approach, see references R1584BABJIDCA–R1584BABEFBIB). If the relevant social cognitive mechanisms can be reliably characterized and shown to be heritable, this approach could lead to more definitive linkage results and to the elucidation of the genetic background of the illnesses in which persecutory delusions arise."
PsychiatryOnline | American Journal of Psychiatry | Cognitive Neuropsychiatric Models of Persecutory Delusions
The American Journal of Psychiatry, VOL. 158, No. 4
A truly comprehensive model of the persecutory delusion requires further elucidation at the neurochemical and genetic levels.
Finally, genetic studies, in the absence of a definitively linked genomic region of, for example, schizophrenia R1584BABBEHIC, currently are being designed to reduce genetic heterogeneity at the entry point of proband ascertainment. Thus, dimensional variables (e.g., delusional ideation, social cognitive skills) or symptom clusters (e.g., reality distortion) become intermediate phenotypes worthy of study (for preliminary examples of this approach, see references R1584BABJIDCA–R1584BABEFBIB). If the relevant social cognitive mechanisms can be reliably characterized and shown to be heritable, this approach could lead to more definitive linkage results and to the elucidation of the genetic background of the illnesses in which persecutory delusions arise."
PsychiatryOnline | American Journal of Psychiatry | Cognitive Neuropsychiatric Models of Persecutory Delusions
The American Journal of Psychiatry, VOL. 158, No. 4
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