Friday, March 1, 2013

Autism spectrum disorder, attention-deficit/hyperactivity disorder, bipolar disorder, major depressive disorder and schizophrenia all share common genetic risk factors, according to the results of the largest genetic study of psychiatric disorders to date

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via Psychiatric News Alert by noreply@blogger.com (Psychiatric News Alert) on 3/1/13
In a study published in the Lancet, the Cross-Disorder Group of the Psychiatric Genomics Consortium, supported by the National Institute of Mental Health, has performed a genomewide single-nucleotide-polymorphism (SNP) data analysis seeking to identify specific variants underlying genetic effects shared between the following five disorders: autism spectrum disorder, attention-deficit/hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia.

Their study is the largest to date and the first to provide evidence that specific SNPs are significantly associated with a range of psychiatric disorders. In particular, they pointed to the effects of voltage-gated calcium channels on such disorders: "Our results implicate a specific biological pathway—voltage-gated calcium-channel signaling—as a contributor to the pathogenesis of several psychiatric disorders and support the potential of this pathway as a therapeutic target for psychiatric disease."


"These important findings indicate that fundamental alterations in brain development and biology can confer vulnerability to various types of mental disorders....," Jeffrey Lieberman, M.D., president-elect of APA told Psychiatric News." Overall, the study provides an important new clue about the etiology and pathogenesis of mental disorders."

APA President Dilip Jeste, M.D., also commented: "Research of this type would help in the development of future diagnostic systems in psychiatry that are based on validated biomarkers...this important study is one step in that direction."
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TIME

International research group finds genetic link among five major psychiatric ...
Public Radio International PRI
International research group finds genetic link among five major psychiatric diseases. Home | Stories | Health and Medicine | International research group finds genetic link among five major psychiatric diseases. Font size: Decrease font Enlarge font ...
5 Disorders Share Genetic Risk Factors, Study FindsNew York Times
Share via e-mailBoston Globe
Five major psychiatric disorders, including autism and bipolar disorder ...GlobalPost
TIME -The Conversation -TopNews New Zealand
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Largest study reveals five major psychiatric disorders share common genetic ...
Medical Xpress
These findings are particularly relevant in view of the imminent revision of classifications in the Diagnostic and Statistical Manual of Mental Disorders (DSM) and the International Classification of Diseases (ICD)." Writing in a linked Comment ...


Autism, Depression Genetically Linked
ABC News
The results are "new evidence that may inform a move beyond descriptive syndromes in psychiatry and towards classification based on underlying causes," Smoller said in a statement. Read this story on www.medpagetoday.com. The findings are especially ...


Times of India

International research group finds genetic link among five major psychiatric ...
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International research group finds genetic link among five major psychiatric diseases. Home | Stories | Health and Medicine | International research group finds genetic link among five major psychiatric diseases. Font size: Decrease font Enlarge font ...
5 Psychiatric disorders share genetic linkTimes of India
Study points to "shared biology" between 5 psychiatric disordersCBS News
Share via e-mailBoston Globe
The Takeaway -UPI.com (blog)
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Children with autism had higher levels of toxic metals
Healio
Researchers reported that children with autism had higher levels of toxic metals in their blood and urine vs. healthy children. The levels of those toxic metals were associated with the severity of the disorder. “These significant associations may ...

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5 Psych Disorders Have Common Genetics
MedPage Today
The results are "new evidence that may inform a move beyond descriptive syndromes in psychiatry and towards classification based on underlying causes," Smoller said in a statement. The findings are especially important because of revisions to the ...


Five Major Psychiatric Disorders Genetically Linked
Medscape
"These findings are particularly relevant in view of the imminent revision of classifications in the Diagnostic and Statistical Manual of Mental Disorders and the International Classification of Diseases," said Dr. Smoller. The investigators add that ...


Times of India

International research group finds genetic link among five major psychiatric ...
Public Radio International PRI
International research group finds genetic link among five major psychiatric diseases. Home | Stories | Health and Medicine | International research group finds genetic link among five major psychiatric diseases. Font size: Decrease font Enlarge font ...
5 Psychiatric disorders share genetic linkTimes of India
Study points to "shared biology" between 5 psychiatric disordersCBS News
Autism, schizophrenia, and other psychiatric disorders share genetic ...Boston.com (blog)
Wall Street Journal -UPI.com (blog) -The Takeaway
all 57 news articles »
 

via DSM5 in Distress by Allen J. Frances, M.D. on 3/1/13
A new way that DSM-5 mislabels the medically ill. Stress, risks factors, noncompliance, and unhealthy lifestyles will now be called a mental disorder.read more


Anti-Soviet 'Psychiatric' prisoners want diagnoses reversed
Deutsche Welle (press release)
The film, “The Dissident," portrayed a 53-year-old Latvian lawyer who was locked up for many years in psychiatric hospitals. This kind of thing, it seems, was not an isolated incident. From the late 1960s to the mid 1980s, a group of Latvians were ...


Five Major Psychiatric Disorders Share Genetic Link
Medical News Today
These findings are particularly relevant in view of the imminent revision of classifications in the Diagnostic and Statistical Manual of Mental Disorders (DSM) and the International Classification of Diseases (ICD)." In a linked editorial comment ...


UConn Advance (blog)

UConn Researchers Impacting Mental Health Treatment in Prison Population
UConn Advance (blog)
Researchers at the University of Connecticut Health Center are making significant contributions to the treatment of mental illness in prisoners, with their efforts earning international recognition and continued federal grant funding. With current ...


Five Major Psychiatric Disorders Share Genetic Link
Medical News Today
These findings are particularly relevant in view of the imminent revision of classifications in the Diagnostic and Statistical Manual of Mental Disorders (DSM) and the International Classification of Diseases (ICD)." In a linked editorial comment ...


Anti-Soviet 'Psychiatric' prisoners want diagnoses reversed
Deutsche Welle (press release)
The film, “The Dissident," portrayed a 53-year-old Latvian lawyer who was locked up for many years in psychiatric hospitals. This kind of thing, it seems, was not an isolated incident. From the late 1960s to the mid-80s, a group of Latvians were ...

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via NIMH | Recent Updates by Jules Asher on 3/1/13
Five major mental disorders share some of the same genetic risk factors, the largest genome-wide study of its kind has found.

via Uploads by NIMHgov by NIMHgov on 3/1/13
National Institutes of Health-funded researchers discovered that people with disorders traditionally thought to be distinct -- autism, ADHD, bipolar disorder, major depression and schizophrenia -- were more likely to have suspect genetic variation at the same four chromosomal sites. These included risk versions of two genes that regulate the flow of calcium into cells. Bruce Cuthbert, Ph.D., director of NIMH's Division of Adult Translational Research, explains the significance of the study findings for diagnosis and treatment of mental illnesses.
From:NIMHgov
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Autism spectrum disorder, attention-deficit/hyperactivity disorder, bipolar disorder, major depressive disorder and schizophrenia all share common genetic risk factors, according to the results of the largest genetic study of psychiatric disorders to date.“This study indicates that some specific genetic variants confer risk to a range of psychiatric disorders that are treated as clinically distinct,” study researcher Jordan Smoller, MD, of Massachusetts General Hospital in Boston, told Psychiatric Annals. “The findings also highlight the role of calcium channel genes, which may provide a treatment target that is relevant to a range of psychiatric disorders.”
 

Five major psychiatric disorders may share common genetic risk factors - Healio


Healio

Five major psychiatric disorders may share common genetic risk factors
Healio
Autism spectrum disorder, attention-deficit/hyperactivity disorder, bipolar disorder, major depressive disorder and schizophrenia all share common genetic risk factors, according to the results of the largest genetic study of psychiatric disorders to date.

and more »