Friday, May 11, 2012

3:27 PM 5/11/2012 - Mike Nova's starred items: Can You Call a 9-Year-Old a Psychopath? - NYTimes

Google Reader - Mike Nova's starred items


3:27 PM 5/11/2012 - Mike Nova's starred items

via NYT > Health by By JENNIFER KAHN on 5/11/12
Psychologists now believe fledgling psychopaths can be identified as early as kindergarten. The hope is to teach these children empathy before it’s too late.



Scientific American


Guideline Revisions May Sharply Increase Addiction Diagnoses
New York Times
“The chances of getting a diagnosis are going to be much greater, and this will artificially inflate the statistics considerably,” said Thomas F. Babor, a psychiatric epidemiologist at the University of Connecticut who is an editor of the international ...
DSM-5 Field Trials Generate Mixed ResultsMedscape
The Gloom-and-Doom Disease: Should Woody Allens Have a Home in the Manual of ...Scientific American (blog)

all 92 news articles »

via psychiatry - Google News on 5/11/12


Changes to autism manual
Gainesville Sun
It will be the fifth edition of what's called the Diagnostic and Statistical Manual for Mental Disorders, or DSM, a guide book in psychiatry. The new manual will include changes to the way autism is diagnosed and will help improve treatment for those ...

and more »

via Psychiatric Times on 5/11/12
Amid all the Super Bowl-esque hoopla of this year’s annual meeting of the American Psychiatric Association was the final round of a national competition among residency programs to demonstrate superior psychiatric knowledge. The several month competition, MindGames, pitted program against program on timed multiple choice exams on a diverse range of psychiatric topics, including theory, psychopharmacology, psychotherapy, geriatrics, addictions, and forensics.

via international psychiatry - Google Blog Search by averderame on 5/11/12
It is an honor to be in Philadelphia, the city of “brotherly love”, as one voice among many in this Occupation of the American Psychiatric Association, brilliantly organized by MindFreedom International. It is an honor to be a part ...

Reports here provided what may be the last public update on DSM-5, the next edition of American psychiatry's diagnostic guide, before it is formally released in May 2013. Many changes have been made since the first draft of ...

The DSM-V goal to effect a “paradigm shift” in psychiatric diagnosis is absurdly premature. Simply stated, descriptive psychiatric diagnosis does not now need and cannot support a paradigm shift. There can be no dramatic ...

via NYT > Health by By KEVIN SACK on 5/11/12
A shift by the federal government in how it pays for drugs for dialysis patients may have had an unintended and potentially dire consequence, researchers say.


via NYT > Health by By ANDREW POLLACK on 5/11/12
Government advisers recommended that the F.D.A. approve the weight-loss drug lorcaserin.



Mike Nova's starred items


US Navy SEALs Blog & Information


Army to study use of 'off label' drugs to treat PTSD
Stars and Stripes
Gary Wynn, a research psychiatrist from the Center for Military Psychiatry and Neuroscience at the Walter Reed Army Institute of Research, said in the release. “Much of the current pharmacologic treatment of combat-related PTSD is off-label and, ...
Tetris: A 'vaccine' for PTSD?HLNtv.com
Army launches study of PTSD medsAirForceTimes.com
PTSD: Weakness or Wound?TIME (blog)
US Navy SEALs Blog & Information (blog)
all 24 news articles »

via psychiatry - Google News on 5/11/12

Scientific American (blog)


Psychiatrists say diagnosis manual needs overhaul
Chicago Tribune
LONDON (Reuters) - Many psychiatrists believe a new edition of a manual designed to help diagnose mental illness should be shelved for at least a year for further revisions, despite some modifications which eliminated two controversial diagnoses.
Why Are There No Biological Tests in Psychiatry?Scientific American (blog)
Panel suggests DSM-5 psychiatry manual drops two disorders, keeps new autism ...CBS News
Psychiatry Manual Drafters Back Down on DiagnosesNew York Times
Fox News
all 89 news articles »

via Behavior and Law by Mike Nova on 5/11/12
Psychiatrists say diagnosis manual needs overhaul - chicagotribune.com

Psychiatrists say diagnosis manual needs overhaul

A patient looks through a window inside the Larco Herrera psychiatric hospital in Lima
A patient looks through a window inside the Larco Herrera psychiatric hospital in Lima (ENRIQUE CASTRO-MENDIVIL, REUTERS / May 10, 2012)




Kate Kelland Reuters
1:24 p.m. CDT, May 10, 2012


LONDON (Reuters) - Many psychiatrists believe a new edition of a manual designed to help diagnose mental illness should be shelved for at least a year for further revisions, despite some modifications which eliminated two controversial diagnoses.

The new edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM 5), a draft of which is open for public consultation this month, will be the first full revision since 1994 of the renowned handbook, which determines how to interpret symptoms in order to diagnose mental illnesses.

But more than 13,000 health professionals from around the world have already signed an open letter petition (at http://dsm5-reform.com) calling for DSM 5 to be halted and re-thought.

"Fundamentally, it remains a bad system," said Peter Kinderman, a professor of clinical psychology at Britain's Liverpool University.

"The very minor revisions...do not constitute the wholesale revision that is called for," he said in an emailed comment.

The American Psychiatric Association (APA), which produces the manual and plans to publish DSM 5 next May, said on Wednesday it had decided to drop two proposed diagnoses, for "attenuated psychosis syndrome" and "mixed anxiety depressive disorder".

The former, intended to help identify people at risk of full-blown psychosis, and the latter, which suggested a blend of anxiety and depression, had been criticized as too ill-defined.

With these and other new diagnoses such as "oppositional defiant disorder" and "apathy syndrome", experts said the draft DSM 5 could define as mentally ill millions of healthy people - ranging from shy or defiant children to grieving relatives, to people with harmless fetishes.

"SIMPLY NOT USABLE"

Robin Murray, a professor of psychiatric research at the Institute of Psychiatry at Kings College London, said it was a great relief to see the changes in the draft, particularly to the attenuated psychosis diagnosis.

"It would have done a lot of harm by diverting doctors into thinking about imagined risk of psychosis (and) it would have led to unnecessary fears among patients that they were about to go mad," he said in a statement.

But Allen Frances, emeritus professor at Duke University in the United States, said it was "only a first small step toward desperately needed DSM 5 reform".

"Numerous dangerous suggestions remain, Frances, who chaired a committee overseeing the DSM 4, said, adding that DSM 5 "is simply not usable" and should be delayed for an extra year "to allow for independent review, to clean up its obscure writing, and for retesting".

Diagnosis is always controversial in psychiatry, since it defines how patients will be treated based on a cluster of symptoms, many of which occur in several different types of mental illness.

Peter Jones, a professor of psychiatry at Cambridge University, said DSM 5 should be "underpinned by science" built on an understanding of the biology and functions of the brain and mind - something he said neuroscience was not yet able to do comprehensively enough.


"On this basis DSM 5 is, at best, premature and a waste of time," he said.

Some argue that the whole approach needs to be changed to pay more attention to individual circumstances rather than slotting them into predefined categories.

Lucy Johnstone, a consultant clinical psychologist for the Cwm Taf Health Board in Wales agreed: "(The DSM)is wrong in principle, based as it is on redefining a whole range of understandable reactions to life circumstances as 'illnesses', which then become a target for toxic medications heavily promoted by the pharmaceutical industry," she said.

"The DSM project cannot be justified, in principle or in practice. It must be abandoned so that we can find more humane and effective ways of responding to mental distress."

One of the proposed changes that has survived in the draft DSM 5 - despite fierce public outcry - is in autism. The new edition eliminates the milder diagnosis of Asperger syndrome in favor of the umbrella diagnosis of autism spectrum disorder.

(Editing by Myra MacDonald)
Copyright © 2012, Reuters
sns-rt-us-psychiatry-dsmbre8490wq-20120510
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Full coverage



Psychiatrists say diagnosis manual needs overhaul

Ottawa Citizen - ‎13 seconds ago‎
By Kate Kelland, Reuters May 11, 2012 9:13 AM Experts say the draft DSM 5 could define as mentally ill millions of healthy people - ranging from shy or defiant children to grieving relatives, to people with harmless fetishes.

Reuters Health News Summary

Chicago Tribune - ‎1 hour ago‎
Following is a summary of current health news briefs. Psychiatrists say diagnosis manual needs overhaul LONDON (Reuters) - Many psychiatrists believe a new edition of a manual designed to help diagnose mental illness should be shelved for at least a ...

Battle looms in psychiatry world over controversial manual update

Montreal Gazette - ‎4 hours ago‎
'Numerous dangerous suggestions remain'despite revisions LONDON – Many psychiatrists believe a new edition of a manual designed to help diagnose mental illness should be shelved for at least a year for further revisions, despite some modifications ...

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  • via psychiatry - Google Blog Search by Brett Blume on 5/11/12
    Will help define was is, and isn't, covered by insurance.

    He said he hopes the document, which is due to be published in May 2013, will lead to greater innovation in psychiatric research and practice. “We need find ways of unshackling science that will encourage scientists to ...

    via psychiatry research - Google Blog Search by unknown on 5/10/12
    I had the chance to speak with him recently to discuss how there's such a broad disconnect between psychiatric research and the common perception of how psychiatric issues are solved. Motherboard: You wrote in your introduction to ...


    Scientific American (blog)


    Psychiatrists say diagnosis manual needs overhaul
    Montreal Gazette
    Many psychiatrists believe a new edition of a manual designed to help diagnose mental illness should be shelved for at least a year for further revisions, despite some modifications which eliminated two controversial diagnoses.
    Why Are There No Biological Tests in Psychiatry?Scientific American (blog)
    Two Disputed Psychiatric Diagnoses Dropped From Revised DSMHuffington Post
    Panel suggests DSM-5 psychiatry manual drops two disorders, keeps new autism ...CBS News
    New York Times
    all 88 news articles »

    via Behavior and Law by Mike Nova on 5/11/12
    Google Reader - General Psychiatry News



    Alzheimer's research fraud case set for trial
    Chicago Tribune
    The lawsuit accuses Marilyn Albert, a former professor of psychiatry at Harvard Medical School, and Massachusetts General Hospital (MGH), where she was conducting research, of submitting a grant application based on manipulated data.

    and more »

    via Behavior and Law by Mike Nova on 5/11/12




    Alzheimer's research fraud case set for trial
    Chicago Tribune
    The lawsuit accuses Marilyn Albert, a former professor of psychiatry at Harvard Medical School, and Massachusetts General Hospital (MGH), where she was conducting research, of submitting a grant application based on manipulated data.

    and more »

    Alzheimer's research fraud case set for trial - chicagotribune.com

    www.chicagotribune.com/news/sns-rt-us-science-fraudbre8491n5-20120510,0,2693773.story

    chicagotribune.com

    Alzheimer's research fraud case set for trial


    Toni Clarke

    Reuters

    6:34 PM CDT, May 10, 2012


    BOSTON (Reuters) - Two Harvard teaching hospitals and a prominent Alzheimer's disease researcher accused of using falsified data to obtain a government research grant are set to stand trial after a federal appeals court said this week that a lower court erred when it dismissed the case.

    The lawsuit accuses Marilyn Albert, a former professor of psychiatry at Harvard Medical School, and Massachusetts General Hospital (MGH), where she was conducting research, of submitting a grant application based on manipulated data.


    The data showed results from a trial were scientifically significant when in fact they were not, according to the lawsuit.

    Brigham and Women's Hospital, which collaborated on the research, is also a defendant in the case. The lawsuit was brought in 2006 under the False Claims Act, a 150-year-old federal law designed to recover government funds appropriated through fraud.

    This is the first time a lawsuit dealing with alleged scientific fraud has been allowed to progress to trial under the False Claims Act, according to Michael Kohn, a lawyer with Kohn, Kohn & Colapinto in Washington, D.C.

    Kohn represents the whistle-blower in the case, Kenneth Jones, a former statistician at Massachusetts General Hospital, who filed suit in 2006 claiming the defendants violated the act by including false statements in a $15 million grant application to the National Institutes of Health (NIH).

    The case was dismissed in the lower court three days before it was due to go to trial. Barring settlement, a new trial could begin later this year in U.S. District Court in Boston, Kohn said.

    If the defendants are found guilty, they could pay as much as $45 million to the U.S. government. By law, whistle-blowers in such cases receive 15 percent to 30 percent of funds recovered.

    Albert, who is now director of the Division of Cognitive Neuroscience at Johns Hopkins University School of Medicine, declined to comment except to say in an email: "I am confident that there was no misconduct involved."

    Both hospitals said they are confident the researchers acted appropriately and according to the highest standards of scientific integrity.

    "While it is disappointing that additional time and resources will have to be devoted to defending the institution and its investigators, the MGH remains confident that the resolution of the case will show that the allegations are without merit," Massachusetts General said in a statement.

    Brigham and Women's responded with an identical statement.

    INFLUENTIAL RESEARCH

    Albert's research was part of an ongoing investigation into the structure of the brain as it progresses toward Alzheimer's disease. She specifically hoped to show that it might be possible to predict, years in advance, who might be destined to develop the disease, based on measurements taken over time of certain regions of the brain.

    The results of the trial were published in the scientific journal Annals of Neurology in April 2000 and, according to Jones, proved extremely influential.


    "The data appeared to confirm what had been suspected by some very prominent scientists, which is that Alzheimer's disease is associated with decreased blood flow to the brain," Jones said in an interview on Thursday. "The MRIs showed the volume of certain parts of the brain was decreasing in the people who were sick."

    There are multiple theories about the cause of Alzheimer's disease.

    In March 2001, Jones discovered what he believed to be anomalies in the research, specifically in data produced by one of the researchers, Ronald Killiany. The lawsuit alleges that Killiany revised his initial MRI measurements to prove the hypothesis of the trial.


    Killiany, now an associate professor at Boston University School of Medicine, did not return a phone call or email seeking comment. Kohn said he was not named as a defendant. In retrospect, Kohn said, "He probably should have been."


    Jones took his concerns to Albert, who authorized an investigation into the matter by Killiany's boss, Mark Moss. She declined to appoint an independent investigator, as requested by Jones, according to the lawsuit.


    Moss concluded that Killiany's second set of measurements was more accurate than the initial set. Albert accepted Moss's conclusion and proceeded to apply for an NIH grant in November 2001, according to the lawsuit.


    The defense argued before the appeals court that it would not have been unusual or inappropriate for Killiany to re-measure patient brain scans as long as he remained blind to the clinical status of the participants, and that this was a matter for scientific debate.


    This argument was accepted when the case was initially heard by the lower court in the United States District Court for the District of Massachusetts. On that basis, it dismissed the case in October 2010. Kohn said

    the court ruled that scientific fraud could not be brought under the False Claims Act, since the case related to a scientific dispute, not fraud.


    The appeals court, however, rejected the argument, saying, "We disagree that the creation of the data in question was necessarily a matter of scientific judgment."



    The court noted that the lower court's determination "misses the point that the various results produced in this case were obtained by one scientist purportedly using the same protocol."


    The government's Office of Research Integrity declined to say whether it is investigating the case.

    Jones said he hopes the trial will shed light on the issue of scientific misconduct.

    "My interest is in correcting the science and bringing this academic cheating to light," he said, "and maybe sending a message saying, 'You're being watched, and you shouldn't do it.'"

    The case is: U.S. ex rel. Jones v. Brigham and Women's Hospital, et al, 1st U.S. Circuit Court of Appeals, No: 10-2301.

    (Editing by Michele Gershberg and Douglas Royalty)
    Copyright © 2012, Reuters

    Public Disturbance at Mass Killer Trial in Norway - YouTube

    Public Disturbance at Mass Killer Trial in Norway - YouTube


    Published on May 11, 2012 by
    The trial of Norwegian mass killer Anders Breivik was stopped today. After a man identified as the older brother of one of the victims, threw a shoe at him, during his trial on Friday.

    Anders Breivik - YouTube

    Anders Breivik - YouTube

    Thumbnail0:52

    A Man Tried To Hit Breivik With a Shoe inside Court Today, but Instead Hit His Lawyer

    Brevik says: If someone likes to throw things, then you can just throw it on me and not my lawyer. This happened after a man tried to throw a shoe ...
    bytrise8117 minutes ago4 views
    Thumbnail1:18

    Public Disturbance at Mass Killer Trial in Norway

    The trial of Norwegian mass killer Anders Breivik was stopped today. After a man identified as the older brother of one of the victims, threw a ...
    byIBTimesUK28 minutes ago0 views
    Thumbnail1:21

    3.flv.MP4

    The trial of Anders Behring Breivik takes a break after a shoe is thrown at the mass killer by the brother of one of the victims. Sunita ...
    bybdnews24DOTcom1 hour ago0 views

    Norway's mass killer Anders Breivik speaks at start of trial - YouTube

    Norway's mass killer Anders Breivik speaks at start of trial - YouTube


    Published on Apr 16, 2012 by
    Anders Breivik speaks at the beginning of his trial to say he does not recognise the Norweigan court. . Report by Sophie Foster. Like us on Facebook at http://www.facebook.com/itn and follow us on Twitter at http://twitter.com/itn

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    The Associated Press: Nigeria island prison offers nation's dark history

    The Associated Press: Nigeria island prison offers nation's dark history

    Nigeria island prison offers nation's dark history
    ITA OKO ISLAND, Nigeria (AP) — The prison, cut out of the dense jungle that engulfs this island outside Lagos, never officially existed in records, though critics of Nigeria's military rulers were locked up here decades ago in harsh conditions.
    Ita Oko Island, accessible only by boat and helicopter, allowed Nigeria's military governments to hold opponents far from public scrutiny in the swamps of Lekki Lagoon. A newspaper expose in 1988 forced officials to close the prison, though local authorities later reopened it for what appears to be a failed $1 million effort to rehabilitate the gang members who dominate Lagos' streets.
    As Nigeria plans to open another classified facility to hold and interrogate members of a radical Islamist sect, the Ita Oko Island prison's failed state shows the dangers posed by operating secret prisons and stands as a haunting reminder of past abuses of power that seem quickly forgotten.
    "We're in the same situation as far as I am concerned as we were in 20 or 30 years ago, but the scenarios and the narrative are different," said Olisa Agbakoba, a lawyer whose civil rights group helped expose the prison. "We have a rapacious political party in power determined to do everything to retain power and the struggle for power is so intense now that I would not put it past the ruling party to conceal anything to keep it power, including abuses of human rights."
    The prison island sits about 100 kilometers (60 miles) outside of Lagos, a rural area where villagers still make a living fishing along the long white sand beaches of the Atlantic Ocean. The 10 square-kilometer (4 square-mile) island is just inland in the lagoon, a wide expanse of water only lightly traveled by locals.
    In 1978, then-military ruler Olusegun Obasanjo, who would become the country's elected president, opened the prison he later described as a work farm. But it wasn't until military ruler Muhammadu Buhari, now a perennial presidential candidate, that the prison became a massive holding cell for political prisoners, Agbakoba said.
    Under a Buhari decree, anyone deemed by the military government to be a security risk could be imprisoned. Though such sentences were to last only a few months, many saw themselves detained indefinitely in Nigeria's mismanaged prisons.
    Those deemed to be a major risk politically found themselves taken to Ita Oko by helicopter, where they worked on the farm and had no contact with the outside world, Agbakoba said. Even today, as the country has become a democracy with the guise of free information laws, it remains unclear how many inmates died on the prison island.
    "It was abused by prison authorities," Agbakoba said. "If you misbehave, they said we'll send you as punishment to" the island.
    In 1988, the wife of one inmate who discovered her husband had been sent there slipped a note to Nobel laureate Wole Soyinka. Soyinka was on the board of Agbakoba's Civil Liberties Organization, which later traveled to the island with a journalist from The Guardian newspaper who published a story exposing the prison. Authorities quickly closed the prison.
    In recent years, Lagos state government said it invested about $1 million to rehabilitate the island into a training center for gang members, known locally as "area boys." But a recent trip to the island by Associated Press journalists found some of the buildings in ruins after what looked like an attack. Fire destroyed some areas, with television sets and other equipment broken on the ground. State government files littered the floor, though a wall clock continued to run on a battery — suggesting whatever happened occurred recently.
    Razor wire and security cameras sat on a 3-meter fence that surrounded what appeared to be dormitories for the site. The main entrance to that area had been padlocked. Someone also left the bones of a small animal on the gate — a black magic warning to stay away.
    Locals from nearby villages said the gang members there had rioted some months ago and escaped. They later came back to free other gang members and destroy more of the property, the locals said.
    Lateef Aderemi Ibirogba, the Lagos state commissioner for information and strategy, did not respond to questions from the AP about the facility.
    That secret prisons can exist — and an apparently violent riot can go unreported — show the ability of Nigeria's government to keep its citizens unaware. The AP has reported that the Nigerian government now is opening a secret detention center for members of the radical Islamist sect known as Boko Haram, which has been blamed for killing more than 520 people this year alone.
    Meanwhile, alleged members of the sect arrested in recent months and accused of killing a British and Italian hostage in Sokoto and the Dec. 25 bombing of a Catholic church outside the capital Abuja that killed at least 44 people have yet to appear in a public court hearing. It remains unclear where they are being held.
    ___
    Associated Press writer Lekan Oyekanmi contributed to this report.
    Jon Gambrell can be reached at www.twitter.com/jongambrellap.

    Man aims shoe at Breivik, marking first outburst in surprisingly calm trial - Christian Science Monitor - Friday, May 11, 2012 - Behavior and Law

    Behavior and Law

    Forensic Psychiatry News


    Scans Show Psychopaths Have Brain Abnormalities - PsychCentral.com - General Psychiatry News

    Google Reader - General Psychiatry News


    PsychCentral.com

    Scans Show Psychopaths Have Brain Abnormalities
    PsychCentral.com
    By Janice Wood Associate News Editor The study, published in the Archives of General Psychiatry and led by researchers at King's College London, also confirmed that psychopathy is a distinct sub-group of antisocial personality disorder (ASPD), ...
    Psychopaths' brains display abnormalitiesVictoria Times Colonist
    Psychopathy Linked to Specific Structural Abnormalities in the BrainScience Daily (press release)
    Psychopaths' brains are different from others'Times of India
    Brisbane Times
    all 11 news articles »

    Alzheimer's research fraud case set for trial - chicagotribune.com



    Alzheimer's research fraud case set for trial
    Chicago Tribune
    The lawsuit accuses Marilyn Albert, a former professor of psychiatry at Harvard Medical School, and Massachusetts General Hospital (MGH), where she was conducting research, of submitting a grant application based on manipulated data.

    and more »

    Alzheimer's research fraud case set for trial - chicagotribune.com

    www.chicagotribune.com/news/sns-rt-us-science-fraudbre8491n5-20120510,0,2693773.story

    chicagotribune.com

    Alzheimer's research fraud case set for trial


    Toni Clarke

    Reuters

    6:34 PM CDT, May 10, 2012


    BOSTON (Reuters) - Two Harvard teaching hospitals and a prominent Alzheimer's disease researcher accused of using falsified data to obtain a government research grant are set to stand trial after a federal appeals court said this week that a lower court erred when it dismissed the case.

    The lawsuit accuses Marilyn Albert, a former professor of psychiatry at Harvard Medical School, and Massachusetts General Hospital (MGH), where she was conducting research, of submitting a grant application based on manipulated data.


    The data showed results from a trial were scientifically significant when in fact they were not, according to the lawsuit.

    Brigham and Women's Hospital, which collaborated on the research, is also a defendant in the case. The lawsuit was brought in 2006 under the False Claims Act, a 150-year-old federal law designed to recover government funds appropriated through fraud.

    This is the first time a lawsuit dealing with alleged scientific fraud has been allowed to progress to trial under the False Claims Act, according to Michael Kohn, a lawyer with Kohn, Kohn & Colapinto in Washington, D.C.

    Kohn represents the whistle-blower in the case, Kenneth Jones, a former statistician at Massachusetts General Hospital, who filed suit in 2006 claiming the defendants violated the act by including false statements in a $15 million grant application to the National Institutes of Health (NIH).

    The case was dismissed in the lower court three days before it was due to go to trial. Barring settlement, a new trial could begin later this year in U.S. District Court in Boston, Kohn said.

    If the defendants are found guilty, they could pay as much as $45 million to the U.S. government. By law, whistle-blowers in such cases receive 15 percent to 30 percent of funds recovered.

    Albert, who is now director of the Division of Cognitive Neuroscience at Johns Hopkins University School of Medicine, declined to comment except to say in an email: "I am confident that there was no misconduct involved."

    Both hospitals said they are confident the researchers acted appropriately and according to the highest standards of scientific integrity.

    "While it is disappointing that additional time and resources will have to be devoted to defending the institution and its investigators, the MGH remains confident that the resolution of the case will show that the allegations are without merit," Massachusetts General said in a statement.

    Brigham and Women's responded with an identical statement.

    INFLUENTIAL RESEARCH

    Albert's research was part of an ongoing investigation into the structure of the brain as it progresses toward Alzheimer's disease. She specifically hoped to show that it might be possible to predict, years in advance, who might be destined to develop the disease, based on measurements taken over time of certain regions of the brain.

    The results of the trial were published in the scientific journal Annals of Neurology in April 2000 and, according to Jones, proved extremely influential.


    "The data appeared to confirm what had been suspected by some very prominent scientists, which is that Alzheimer's disease is associated with decreased blood flow to the brain," Jones said in an interview on Thursday. "The MRIs showed the volume of certain parts of the brain was decreasing in the people who were sick."

    There are multiple theories about the cause of Alzheimer's disease.

    In March 2001, Jones discovered what he believed to be anomalies in the research, specifically in data produced by one of the researchers, Ronald Killiany. The lawsuit alleges that Killiany revised his initial MRI measurements to prove the hypothesis of the trial.


    Killiany, now an associate professor at Boston University School of Medicine, did not return a phone call or email seeking comment. Kohn said he was not named as a defendant. In retrospect, Kohn said, "He probably should have been."


    Jones took his concerns to Albert, who authorized an investigation into the matter by Killiany's boss, Mark Moss. She declined to appoint an independent investigator, as requested by Jones, according to the lawsuit.


    Moss concluded that Killiany's second set of measurements was more accurate than the initial set. Albert accepted Moss's conclusion and proceeded to apply for an NIH grant in November 2001, according to the lawsuit.


    The defense argued before the appeals court that it would not have been unusual or inappropriate for Killiany to re-measure patient brain scans as long as he remained blind to the clinical status of the participants, and that this was a matter for scientific debate.


    This argument was accepted when the case was initially heard by the lower court in the United States District Court for the District of Massachusetts. On that basis, it dismissed the case in October 2010. Kohn said

    the court ruled that scientific fraud could not be brought under the False Claims Act, since the case related to a scientific dispute, not fraud.


    The appeals court, however, rejected the argument, saying, "We disagree that the creation of the data in question was necessarily a matter of scientific judgment."



    The court noted that the lower court's determination "misses the point that the various results produced in this case were obtained by one scientist purportedly using the same protocol."


    The government's Office of Research Integrity declined to say whether it is investigating the case.

    Jones said he hopes the trial will shed light on the issue of scientific misconduct.

    "My interest is in correcting the science and bringing this academic cheating to light," he said, "and maybe sending a message saying, 'You're being watched, and you shouldn't do it.'"

    The case is: U.S. ex rel. Jones v. Brigham and Women's Hospital, et al, 1st U.S. Circuit Court of Appeals, No: 10-2301.

    (Editing by Michele Gershberg and Douglas Royalty)

    Alzheimer's research fraud case set for trial - Chicago Tribune - General Psychiatry News

    Google Reader - General Psychiatry News


    Alzheimer's research fraud case set for trial
    Chicago Tribune
    The lawsuit accuses Marilyn Albert, a former professor of psychiatry at Harvard Medical School, and Massachusetts General Hospital (MGH), where she was conducting research, of submitting a grant application based on manipulated data.

    and more »

    New Pharmacology and Psychiatry Resources Published at Sciences Social Network - Times Union


    PR Web

    New Pharmacology and Psychiatry Resources Published at Sciences Social Network
    Albany Times Union
    The Pharmacology and Psychiatry Sciences are two new key health categories covered by the Sciences Social Network ScienceIndex.com. The users of the website monitor 217 scientific journals and submit the most significant scientific results of these ...
    New Oncology and Pathology Resources Published at Sciences Social NetworkPR Web (press release)

    all 7 news articles »

    New Pharmacology and Psychiatry Resources Published at Sciences Social Network - Times Union

    New Pharmacology and Psychiatry Resources Published at Sciences Social Network

    Published 10:05 a.m., Thursday, May 10, 2012
    •  Photo: PRWeb / AL
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    PRESS RELEASE

    The company that placed this press release with PRWeb is responsible for its content. It is not edited by the Albany Times Union.
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    The Pharmacology and Psychiatry Sciences are two new key health categories covered by the Sciences Social Network ScienceIndex.com. The users of the website monitor 217 scientific journals and submit the most significant scientific results of these journals for inclusion in these two categories which currently contain a total of 37,387 articles. ScienceIndex.com was established in 1998 to index the very latest news, headlines, references and resources in all fields of biology, business, chemistry, engineering, geography, health, mathematics and society.
    Mannheim, Germany (PRWEB) May 10, 2012
    ScienceIndex.com is a health social network established in 1998 to index the very latest news, headlines, references and resources from science journals, books and websites worldwide. The site covers news in all fields of biology, business, chemistry, engineering, geography, health, mathematics and society. In the field of Health Sciences, the site has now included the two new categories Pharmacology and Psychiatry. While the Pharmacology category covers composition, uses, and effects of drugs, the Psychiatry category covers the diagnosis, treatment, and prevention of mental and emotional disorders.
    ScienceIndex.com's Health Category covers the effects of disease and medical treatment on the overall condition of organisms. Its eighteen subsections include Audiology, Dentistry, Dermatology, Endocrinology, Gastroenterology, Healthcare, Immunology, Medicine, Neurology, Nutrition, Oncology, Pathology, Pharmacology, Psychiatry, Psychology, Radiology, Rheumatology, and Surgery. Users can receive alerts if new content has been posted in this category by subscribing to ScienceIndex.com's Health RSS feed.
    ScienceIndex.com's Pharmacology category covers composition, uses, and effects of drugs. It currently contains 29,615 articles partly derived from 154 scientific journals. The latest articles in this category are also available through an Pharmacology Sciences RSS feed. One of the latest additions assessed the in vivo antitumor efficacy of a polypeptide-based poly-L-glutamic acid-gemcitabine conjugate (PG-G) in tumor-bearing mice. The antitumor effects of PG-G were superior to those of unconjugated gemcitabine in both single and four-consecutive dosing studies. The authors' study demonstrates that the PG-G formulation shows a significant antitumor activity in terms of tumor growth inhibition and shrinkage and that the PG-G dose regimen need to be optimized to minimize side effects and render it a potential anticancer therapeutic. Another recently published article in this category reviews prescribing errors in hospital practice. Errors have been reported in handwritten descriptions of almost 15 percent and with electronic prescribing of up to 8 percent of orders.
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    ScienceIndex.com's Psychiatry category covers the diagnosis, treatment, and prevention of mental and emotional disorders. It currently contains 7,772 articles partly derived from 63 scientific journals. The latest articles in this category are also available through a Psychiatry Sciences RSS feed. One recently included article in this category studies the effect of purpose in life on the relation between Alzheimer disease (AD). The authors tested the hypothesis that purpose in life reduces the deleterious effects of AD pathologic changes on cognition in advanced age. Their results indicate that higher levels of purpose in life reduce the deleterious effects of AD pathologic changes on cognition in advanced age. Another recently published article covers polypharmacy with antipsychotics, antidepressants, or benzodiazepines and mortality in schizophrenia. While polypharmacy is widely used in the treatment of schizophrenia, it is believed to have major adverse effects on the well-being of patients. The authors of this study linked national databases of mortality and medication prescriptions among a complete nationwide cohort of 2,588 patients hospitalized in Finland with a diagnosis of schizophrenia between 2000 and 2007. Benzodiazepine use was associated with a substantial increase in mortality, and this was attributable to suicidal deaths and to nonsuicidal deaths. In contrast, the use of an antidepressant or several concomitant antipsychotics was not associated with an increase in mortality.
    ScienceIndex.com currently contains over 1.46 million stories distributed among 75 categories. 76,341 users monitor nearly 8,400 journals covering the broad spectrum of sciences. Since new science content is discovered in real-time, the delay between original publication and appearance at ScienceIndex.com is no more than two days. ScienceIndex.com provides an advanced search feature which suggests up to ten closely related articles for a search and every selected story.

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