Wednesday, June 20, 2012

9:33 AM 6/20/2012 - Mike Nova's starred items

9:33 AM 6/20/2012 - Mike Nova's starred items


via Twitter / APAPsychiatric on 6/20/12
APAPsychiatric: For the first time in 73 years a psychiatrist becomes president of the AMA. Congratulation to Jeremy Lazarus, MD.

via psychiatry - Google Blog Search by unknown on 6/19/12
The identification of genes and gene products involved in psychiatric disorders should have very important implications for drug therapy in two ways. The first of these is in the direction of drug discovery [73]. Currently the ...

via psychiatry - Google Blog Search by unknown on 6/19/12
Endocrinology and Psychiatry: The Powerful Influence. June 19th | Psychiatry as a Neuroscience. The brain, like any other organ, is constantly exposed to and governed by hormones in the internal medium, as a way to integrate its activities ...

via psychiatry - Google Blog Search by jeantine.vangemund on 6/19/12
The study of human passions has vanished from Western psychiatry and should be restored, according to a visiting professor who will give a free public lecture at The University of Western Australia. Professor Louis Charland ...

via psychiatry - Google Blog Search by King, A. C., de Wit, H., McNamara, P. J., Cao, D. on 4/4/11
Context Excessive consumption of alcohol is a major problem in the United States and abroad. Despite many years of study, it is unclear why some individuals drink alcohol excessively while others do not. It has been ...

via candidaabrahamson by candidaabrahamson on 6/20/12
“I Will Survive!”: But Can You Teach That To The Armed Forces? And, really–can you? That’s the question on everybody’s mind? For we began discussion with the devastating suicide statistics in the military, which contrasted so starkly with those of black women. And then we analyzed what made these women so resilient, frequently despite markedly [...]

via pubmed: psychiatry by pubmed on 6/20/12
86 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:
These pubmed results were generated on 2012/06/20
PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources.

via psychiatric diagnosis - Google Blog Search by stevebMD on 6/19/12
It's a real condition—and medications can help tremendously—but the diagnostic criteria are quite vague. As with much in psychiatry, anyone “saying the right thing” can relatively easily get one of these drugs, whether they ...

Besides being the most enduring hypothesis to explain the molecular and neuropathological findings of AD, the amyloid cascade hypothesis can be used to predict likely disease-modifying targets. The most obvious target is the next generation of amyloid itself. If this can be avoided or mitigated, then it is very likely that the disease process would be interrupted. Inhibition of g-secretase activity could be problematic, as g-secretase inhibitors would also be expected to inhibit the maturation of the notch and therefore could have adverse consequences on haematopoiesis in other processes. BACE inhibitors have been identified and are very intensively studied as potential modifiers of the disease. The increased activity of PKC via an alternative strategy asecretase is accurate, although the caveat remains that has not yet been proven that this will result in a reduction of amyloid itself same. Nevertheless, the great advantage of this strategy is that compounds that increase PKC activity are tried and tested and as cholinergic enhancement compounds? Holinesterase inhibitors, for example) are already in use in the target population. Furthermore, these compounds have also been shown to reduce tau phosphorylation, and “ hit'' the disease process at two sites simultaneously. An alternative approach to the fight against amyloid is to prevent fibrillogenesis of amyloid peptide aggregates or conceal beginning before plaque formation. Compounds that seek to achieve this is to generation. Agents to prevent amyloid formation in AD will be useful, but not frontotemporaldementias the whereasanti-tauaggregationstrategieswould beactiveinbothtypesofdisorder.Tauaggregationitselfisasitefor potential therapeutic intervention, is that phosphorylation of tau. Lithium is a relatively toxic inhibitor of GSK-3, but other less toxic inhibitors of GSK-3 could be of any practical use in AD. Because GSK-3 is inhibited by lithium, these compounds are of considerable interest as potential agents in affective disorders as well.

No comments:

Post a Comment