Neuroimaging in Autism: Fractional anisotropy values - AJP CME Course for June 2012: Differences in White Matter Fiber Tract Development Present From 6 to 24 Months in Infants with Autism
fractional anisotropy values - GS
normal fractional anisotropy values - GS
____________________________________
Fractional anisotropy
From Wikipedia, the free encyclopedia
Fractional anisotropy (FA) is a scalar value between zero and one that describes the degree of anisotropy of a diffusion process. A value of zero means that diffusion is isotropic, i.e. it is unrestricted (or equally restricted) in all directions. A value of one means that diffusion occurs only along one axis and is fully restricted along all other directions. FA is a measure often used in diffusion imaging where it is thought to reflect fiber density, axonal diameter, and myelination in white matter. The FA is an extension of the concept of eccentricity of conic sections in 3 dimensions, normalized to the unit range.
autism neuroimaging fractional anisotropy - Pubmed Search
pubmed: autism neuroimaging ... - RSS
Autism neuroimaging - Fractional anisotropy - pubmed_result
1: Lai G, Pantazatos SP, Schneider H, Hirsch J. Neural systems for speech and
song in autism. Brain. 2012 Mar;135(Pt 3):961-75. Epub 2012 Feb 1. PubMed PMID:
22298195; PubMed Central PMCID: PMC3286324.
2: Corrigan NM, Richards TL, Treffert DA, Dager SR. Toward a better understanding
of the savant brain. Compr Psychiatry. 2011 Dec 27. [Epub ahead of print] PubMed
PMID: 22206802.
3: Ameis SH, Fan J, Rockel C, Voineskos AN, Lobaugh NJ, Soorya L, Wang AT,
Hollander E, Anagnostou E. Impaired structural connectivity of socio-emotional
circuits in autism spectrum disorders: a diffusion tensor imaging study. PLoS
One. 2011;6(11):e28044. Epub 2011 Nov 23. PubMed PMID: 22132206; PubMed Central
PMCID: PMC3223195.
4: Bode MK, Mattila ML, Kiviniemi V, Rahko J, Moilanen I, Ebeling H, Tervonen O,
Nikkinen J. White matter in autism spectrum disorders - evidence of impaired
fiber formation. Acta Radiol. 2011 Dec 1;52(10):1169-74. Epub 2011 Nov 18. PubMed
PMID: 22101385.
5: Hong S, Ke X, Tang T, Hang Y, Chu K, Huang H, Ruan Z, Lu Z, Tao G, Liu Y.
Detecting abnormalities of corpus callosum connectivity in autism using magnetic
resonance imaging and diffusion tensor tractography. Psychiatry Res. 2011 Dec
30;194(3):333-9. Epub 2011 Nov 1. PubMed PMID: 22047729.
6: Fouque AL, Fillard P, Bargiacchi A, Cachia A, Zilbovicius M, Thyreau B, Le
Floch E, Ciuciu P, Duchesnay E. Voxelwise multivariate statistics and brain-wide
machine learning using the full diffusion tensor. Med Image Comput Comput Assist
Interv. 2011;14(Pt 2):9-16. PubMed PMID: 21995007.
7: Ellegood J, Lerch JP, Henkelman RM. Brain abnormalities in a Neuroligin3 R451C
knockin mouse model associated with autism. Autism Res. 2011 Oct;4(5):368-76.
doi: 10.1002/aur.215. Epub 2011 Aug 31. PubMed PMID: 21882360.
8: Cheon KA, Kim YS, Oh SH, Park SY, Yoon HW, Herrington J, Nair A, Koh YJ, Jang
DP, Kim YB, Leventhal BL, Cho ZH, Castellanos FX, Schultz RT. Involvement of the
anterior thalamic radiation in boys with high functioning autism spectrum
disorders: a Diffusion Tensor Imaging study. Brain Res. 2011 Oct 12;1417:77-86.
Epub 2011 Aug 16. PubMed PMID: 21890117.
9: Langen M, Leemans A, Johnston P, Ecker C, Daly E, Murphy CM, Dell'acqua F,
Durston S; AIMS Consortium, Murphy DG. Fronto-striatal circuitry and inhibitory
control in autism: findings from diffusion tensor imaging tractography. Cortex.
2012 Feb;48(2):183-93. Epub 2011 May 30. PubMed PMID: 21718979.
10: Weinstein M, Ben-Sira L, Levy Y, Zachor DA, Ben Itzhak E, Artzi M, Tarrasch
R, Eksteine PM, Hendler T, Ben Bashat D. Abnormal white matter integrity in young
children with autism. Hum Brain Mapp. 2011 Apr;32(4):534-43. doi:
10.1002/hbm.21042. PubMed PMID: 21391246.
11: Lo YC, Soong WT, Gau SS, Wu YY, Lai MC, Yeh FC, Chiang WY, Kuo LW, Jaw FS,
Tseng WY. The loss of asymmetry and reduced interhemispheric connectivity in
adolescents with autism: a study using diffusion spectrum imaging tractography.
Psychiatry Res. 2011 Apr 30;192(1):60-6. Epub 2011 Mar 5. PubMed PMID: 21377337.
12: Shukla DK, Keehn B, Smylie DM, Müller RA. Microstructural abnormalities of
short-distance white matter tracts in autism spectrum disorder. Neuropsychologia.
2011 Apr;49(5):1378-82. Epub 2011 Feb 17. PubMed PMID: 21333661.
13: Lange N, Dubray MB, Lee JE, Froimowitz MP, Froehlich A, Adluru N, Wright B,
Ravichandran C, Fletcher PT, Bigler ED, Alexander AL, Lainhart JE. Atypical
diffusion tensor hemispheric asymmetry in autism. Autism Res. 2010
Dec;3(6):350-8. doi: 10.1002/aur.162. Epub 2010 Dec 2. PubMed PMID: 21182212;
PubMed Central PMCID: PMC3215255.
14: Jou RJ, Jackowski AP, Papademetris X, Rajeevan N, Staib LH, Volkmar FR.
Diffusion tensor imaging in autism spectrum disorders: preliminary evidence of
abnormal neural connectivity. Aust N Z J Psychiatry. 2011 Feb;45(2):153-62. Epub
2010 Dec 6. PubMed PMID: 21128874; PubMed Central PMCID: PMC3123660.
15: Shukla DK, Keehn B, Müller RA. Tract-specific analyses of diffusion tensor
imaging show widespread white matter compromise in autism spectrum disorder. J
Child Psychol Psychiatry. 2011 Mar;52(3):286-95. doi:
10.1111/j.1469-7610.2010.02342.x. Epub 2010 Nov 12. PubMed PMID: 21073464.
16: Groen WB, Buitelaar JK, van der Gaag RJ, Zwiers MP. Pervasive microstructural
abnormalities in autism: a DTI study. J Psychiatry Neurosci. 2011
Jan;36(1):32-40. PubMed PMID: 20964953; PubMed Central PMCID: PMC3004973.
17: Barnea-Goraly N, Lotspeich LJ, Reiss AL. Similar white matter aberrations in
children with autism and their unaffected siblings: a diffusion tensor imaging
study using tract-based spatial statistics. Arch Gen Psychiatry. 2010
Oct;67(10):1052-60. PubMed PMID: 20921121.
18: Noriuchi M, Kikuchi Y, Yoshiura T, Kira R, Shigeto H, Hara T, Tobimatsu S,
Kamio Y. Altered white matter fractional anisotropy and social impairment in
children with autism spectrum disorder. Brain Res. 2010 Nov 29;1362:141-9. Epub
2010 Sep 18. PubMed PMID: 20858472.
19: Chou KH, Cheng Y, Chen IY, Lin CP, Chu WC. Sex-linked white matter
microstructure of the social and analytic brain. Neuroimage. 2011 Jan
1;54(1):725-33. Epub 2010 Jul 12. PubMed PMID: 20633662.
20: Bloemen OJ, Deeley Q, Sundram F, Daly EM, Barker GJ, Jones DK, van Amelsvoort
TA, Schmitz N, Robertson D, Murphy KC, Murphy DG. White matter integrity in
Asperger syndrome: a preliminary diffusion tensor magnetic resonance imaging
study in adults. Autism Res. 2010 Oct;3(5):203-13. Erratum in: Autism Res. 2011
Apr;4(2):160. PubMed PMID: 20625995.
21: Sahyoun CP, Belliveau JW, Mody M. White matter integrity and pictorial
reasoning in high-functioning children with autism. Brain Cogn. 2010
Aug;73(3):180-8. Epub 2010 Jun 12. PubMed PMID: 20542370; PubMed Central PMCID:
PMC2905578.
22: Li Q, Cheung C, Wei R, Cheung V, Hui ES, You Y, Wong P, Chua SE, McAlonan GM,
Wu EX. Voxel-based analysis of postnatal white matter microstructure in mice
exposed to immune challenge in early or late pregnancy. Neuroimage. 2010 Aug
1;52(1):1-8. Epub 2010 Apr 23. PubMed PMID: 20399275.
23: Sivaswamy L, Kumar A, Rajan D, Behen M, Muzik O, Chugani D, Chugani H. A
diffusion tensor imaging study of the cerebellar pathways in children with autism
spectrum disorder. J Child Neurol. 2010 Oct;25(10):1223-31. Epub 2010 Feb 22.
PubMed PMID: 20179000.
24: Tan GC, Doke TF, Ashburner J, Wood NW, Frackowiak RS. Normal variation in
fronto-occipital circuitry and cerebellar structure with an autism-associated
polymorphism of CNTNAP2. Neuroimage. 2010 Nov 15;53(3):1030-42. Epub 2010 Feb 20.
PubMed PMID: 20176116; PubMed Central PMCID: PMC2941042.
25: Fletcher PT, Whitaker RT, Tao R, DuBray MB, Froehlich A, Ravichandran C,
Alexander AL, Bigler ED, Lange N, Lainhart JE. Microstructural connectivity of
the arcuate fasciculus in adolescents with high-functioning autism. Neuroimage.
2010 Jul 1;51(3):1117-25. Epub 2010 Feb 2. PubMed PMID: 20132894; PubMed Central
PMCID: PMC2966943.
26: Cheng Y, Chou KH, Chen IY, Fan YT, Decety J, Lin CP. Atypical development of
white matter microstructure in adolescents with autism spectrum disorders.
Neuroimage. 2010 Apr 15;50(3):873-82. Epub 2010 Jan 11. PubMed PMID: 20074650.
27: Kumar A, Sundaram SK, Sivaswamy L, Behen ME, Makki MI, Ager J, Janisse J,
Chugani HT, Chugani DC. Alterations in frontal lobe tracts and corpus callosum in
young children with autism spectrum disorder. Cereb Cortex. 2010
Sep;20(9):2103-13. Epub 2009 Dec 17. PubMed PMID: 20019145.
28: Pardini M, Garaci FG, Bonzano L, Roccatagliata L, Palmieri MG, Pompili E,
Coniglione F, Krueger F, Ludovici A, Floris R, Benassi F, Emberti Gialloreti L.
White matter reduced streamline coherence in young men with autism and mental
retardation. Eur J Neurol. 2009 Nov;16(11):1185-90. Epub 2009 Jun 15. PubMed
PMID: 19538216.
29: Thakkar KN, Polli FE, Joseph RM, Tuch DS, Hadjikhani N, Barton JJ, Manoach
DS. Response monitoring, repetitive behaviour and anterior cingulate
abnormalities in autism spectrum disorders (ASD). Brain. 2008 Sep;131(Pt
9):2464-78. Epub 2008 Jun 11. PubMed PMID: 18550622; PubMed Central PMCID:
PMC2525446.
30: Lee JE, Bigler ED, Alexander AL, Lazar M, DuBray MB, Chung MK, Johnson M,
Morgan J, Miller JN, McMahon WM, Lu J, Jeong EK, Lainhart JE. Diffusion tensor
imaging of white matter in the superior temporal gyrus and temporal stem in
autism. Neurosci Lett. 2007 Sep 7;424(2):127-32. Epub 2007 Aug 6. PubMed PMID:
17714869.
31: Keller TA, Kana RK, Just MA. A developmental study of the structural
integrity of white matter in autism. Neuroreport. 2007 Jan 8;18(1):23-7. PubMed
PMID: 17259855.
*
CME > AJP CME >
CME > AJP CME >
1.
______________________________________
pubmed: autism neuroimaging ... - RSS
Autism neuroimaging - Fractional anisotropy - pubmed_result
1: Lai G, Pantazatos SP, Schneider H, Hirsch J. Neural systems for speech and
song in autism. Brain. 2012 Mar;135(Pt 3):961-75. Epub 2012 Feb 1. PubMed PMID:
22298195; PubMed Central PMCID: PMC3286324.
2: Corrigan NM, Richards TL, Treffert DA, Dager SR. Toward a better understanding
of the savant brain. Compr Psychiatry. 2011 Dec 27. [Epub ahead of print] PubMed
PMID: 22206802.
3: Ameis SH, Fan J, Rockel C, Voineskos AN, Lobaugh NJ, Soorya L, Wang AT,
Hollander E, Anagnostou E. Impaired structural connectivity of socio-emotional
circuits in autism spectrum disorders: a diffusion tensor imaging study. PLoS
One. 2011;6(11):e28044. Epub 2011 Nov 23. PubMed PMID: 22132206; PubMed Central
PMCID: PMC3223195.
4: Bode MK, Mattila ML, Kiviniemi V, Rahko J, Moilanen I, Ebeling H, Tervonen O,
Nikkinen J. White matter in autism spectrum disorders - evidence of impaired
fiber formation. Acta Radiol. 2011 Dec 1;52(10):1169-74. Epub 2011 Nov 18. PubMed
PMID: 22101385.
5: Hong S, Ke X, Tang T, Hang Y, Chu K, Huang H, Ruan Z, Lu Z, Tao G, Liu Y.
Detecting abnormalities of corpus callosum connectivity in autism using magnetic
resonance imaging and diffusion tensor tractography. Psychiatry Res. 2011 Dec
30;194(3):333-9. Epub 2011 Nov 1. PubMed PMID: 22047729.
6: Fouque AL, Fillard P, Bargiacchi A, Cachia A, Zilbovicius M, Thyreau B, Le
Floch E, Ciuciu P, Duchesnay E. Voxelwise multivariate statistics and brain-wide
machine learning using the full diffusion tensor. Med Image Comput Comput Assist
Interv. 2011;14(Pt 2):9-16. PubMed PMID: 21995007.
7: Ellegood J, Lerch JP, Henkelman RM. Brain abnormalities in a Neuroligin3 R451C
knockin mouse model associated with autism. Autism Res. 2011 Oct;4(5):368-76.
doi: 10.1002/aur.215. Epub 2011 Aug 31. PubMed PMID: 21882360.
8: Cheon KA, Kim YS, Oh SH, Park SY, Yoon HW, Herrington J, Nair A, Koh YJ, Jang
DP, Kim YB, Leventhal BL, Cho ZH, Castellanos FX, Schultz RT. Involvement of the
anterior thalamic radiation in boys with high functioning autism spectrum
disorders: a Diffusion Tensor Imaging study. Brain Res. 2011 Oct 12;1417:77-86.
Epub 2011 Aug 16. PubMed PMID: 21890117.
9: Langen M, Leemans A, Johnston P, Ecker C, Daly E, Murphy CM, Dell'acqua F,
Durston S; AIMS Consortium, Murphy DG. Fronto-striatal circuitry and inhibitory
control in autism: findings from diffusion tensor imaging tractography. Cortex.
2012 Feb;48(2):183-93. Epub 2011 May 30. PubMed PMID: 21718979.
10: Weinstein M, Ben-Sira L, Levy Y, Zachor DA, Ben Itzhak E, Artzi M, Tarrasch
R, Eksteine PM, Hendler T, Ben Bashat D. Abnormal white matter integrity in young
children with autism. Hum Brain Mapp. 2011 Apr;32(4):534-43. doi:
10.1002/hbm.21042. PubMed PMID: 21391246.
11: Lo YC, Soong WT, Gau SS, Wu YY, Lai MC, Yeh FC, Chiang WY, Kuo LW, Jaw FS,
Tseng WY. The loss of asymmetry and reduced interhemispheric connectivity in
adolescents with autism: a study using diffusion spectrum imaging tractography.
Psychiatry Res. 2011 Apr 30;192(1):60-6. Epub 2011 Mar 5. PubMed PMID: 21377337.
12: Shukla DK, Keehn B, Smylie DM, Müller RA. Microstructural abnormalities of
short-distance white matter tracts in autism spectrum disorder. Neuropsychologia.
2011 Apr;49(5):1378-82. Epub 2011 Feb 17. PubMed PMID: 21333661.
13: Lange N, Dubray MB, Lee JE, Froimowitz MP, Froehlich A, Adluru N, Wright B,
Ravichandran C, Fletcher PT, Bigler ED, Alexander AL, Lainhart JE. Atypical
diffusion tensor hemispheric asymmetry in autism. Autism Res. 2010
Dec;3(6):350-8. doi: 10.1002/aur.162. Epub 2010 Dec 2. PubMed PMID: 21182212;
PubMed Central PMCID: PMC3215255.
14: Jou RJ, Jackowski AP, Papademetris X, Rajeevan N, Staib LH, Volkmar FR.
Diffusion tensor imaging in autism spectrum disorders: preliminary evidence of
abnormal neural connectivity. Aust N Z J Psychiatry. 2011 Feb;45(2):153-62. Epub
2010 Dec 6. PubMed PMID: 21128874; PubMed Central PMCID: PMC3123660.
15: Shukla DK, Keehn B, Müller RA. Tract-specific analyses of diffusion tensor
imaging show widespread white matter compromise in autism spectrum disorder. J
Child Psychol Psychiatry. 2011 Mar;52(3):286-95. doi:
10.1111/j.1469-7610.2010.02342.x. Epub 2010 Nov 12. PubMed PMID: 21073464.
16: Groen WB, Buitelaar JK, van der Gaag RJ, Zwiers MP. Pervasive microstructural
abnormalities in autism: a DTI study. J Psychiatry Neurosci. 2011
Jan;36(1):32-40. PubMed PMID: 20964953; PubMed Central PMCID: PMC3004973.
17: Barnea-Goraly N, Lotspeich LJ, Reiss AL. Similar white matter aberrations in
children with autism and their unaffected siblings: a diffusion tensor imaging
study using tract-based spatial statistics. Arch Gen Psychiatry. 2010
Oct;67(10):1052-60. PubMed PMID: 20921121.
18: Noriuchi M, Kikuchi Y, Yoshiura T, Kira R, Shigeto H, Hara T, Tobimatsu S,
Kamio Y. Altered white matter fractional anisotropy and social impairment in
children with autism spectrum disorder. Brain Res. 2010 Nov 29;1362:141-9. Epub
2010 Sep 18. PubMed PMID: 20858472.
19: Chou KH, Cheng Y, Chen IY, Lin CP, Chu WC. Sex-linked white matter
microstructure of the social and analytic brain. Neuroimage. 2011 Jan
1;54(1):725-33. Epub 2010 Jul 12. PubMed PMID: 20633662.
20: Bloemen OJ, Deeley Q, Sundram F, Daly EM, Barker GJ, Jones DK, van Amelsvoort
TA, Schmitz N, Robertson D, Murphy KC, Murphy DG. White matter integrity in
Asperger syndrome: a preliminary diffusion tensor magnetic resonance imaging
study in adults. Autism Res. 2010 Oct;3(5):203-13. Erratum in: Autism Res. 2011
Apr;4(2):160. PubMed PMID: 20625995.
21: Sahyoun CP, Belliveau JW, Mody M. White matter integrity and pictorial
reasoning in high-functioning children with autism. Brain Cogn. 2010
Aug;73(3):180-8. Epub 2010 Jun 12. PubMed PMID: 20542370; PubMed Central PMCID:
PMC2905578.
22: Li Q, Cheung C, Wei R, Cheung V, Hui ES, You Y, Wong P, Chua SE, McAlonan GM,
Wu EX. Voxel-based analysis of postnatal white matter microstructure in mice
exposed to immune challenge in early or late pregnancy. Neuroimage. 2010 Aug
1;52(1):1-8. Epub 2010 Apr 23. PubMed PMID: 20399275.
23: Sivaswamy L, Kumar A, Rajan D, Behen M, Muzik O, Chugani D, Chugani H. A
diffusion tensor imaging study of the cerebellar pathways in children with autism
spectrum disorder. J Child Neurol. 2010 Oct;25(10):1223-31. Epub 2010 Feb 22.
PubMed PMID: 20179000.
24: Tan GC, Doke TF, Ashburner J, Wood NW, Frackowiak RS. Normal variation in
fronto-occipital circuitry and cerebellar structure with an autism-associated
polymorphism of CNTNAP2. Neuroimage. 2010 Nov 15;53(3):1030-42. Epub 2010 Feb 20.
PubMed PMID: 20176116; PubMed Central PMCID: PMC2941042.
25: Fletcher PT, Whitaker RT, Tao R, DuBray MB, Froehlich A, Ravichandran C,
Alexander AL, Bigler ED, Lange N, Lainhart JE. Microstructural connectivity of
the arcuate fasciculus in adolescents with high-functioning autism. Neuroimage.
2010 Jul 1;51(3):1117-25. Epub 2010 Feb 2. PubMed PMID: 20132894; PubMed Central
PMCID: PMC2966943.
26: Cheng Y, Chou KH, Chen IY, Fan YT, Decety J, Lin CP. Atypical development of
white matter microstructure in adolescents with autism spectrum disorders.
Neuroimage. 2010 Apr 15;50(3):873-82. Epub 2010 Jan 11. PubMed PMID: 20074650.
27: Kumar A, Sundaram SK, Sivaswamy L, Behen ME, Makki MI, Ager J, Janisse J,
Chugani HT, Chugani DC. Alterations in frontal lobe tracts and corpus callosum in
young children with autism spectrum disorder. Cereb Cortex. 2010
Sep;20(9):2103-13. Epub 2009 Dec 17. PubMed PMID: 20019145.
28: Pardini M, Garaci FG, Bonzano L, Roccatagliata L, Palmieri MG, Pompili E,
Coniglione F, Krueger F, Ludovici A, Floris R, Benassi F, Emberti Gialloreti L.
White matter reduced streamline coherence in young men with autism and mental
retardation. Eur J Neurol. 2009 Nov;16(11):1185-90. Epub 2009 Jun 15. PubMed
PMID: 19538216.
29: Thakkar KN, Polli FE, Joseph RM, Tuch DS, Hadjikhani N, Barton JJ, Manoach
DS. Response monitoring, repetitive behaviour and anterior cingulate
abnormalities in autism spectrum disorders (ASD). Brain. 2008 Sep;131(Pt
9):2464-78. Epub 2008 Jun 11. PubMed PMID: 18550622; PubMed Central PMCID:
PMC2525446.
30: Lee JE, Bigler ED, Alexander AL, Lazar M, DuBray MB, Chung MK, Johnson M,
Morgan J, Miller JN, McMahon WM, Lu J, Jeong EK, Lainhart JE. Diffusion tensor
imaging of white matter in the superior temporal gyrus and temporal stem in
autism. Neurosci Lett. 2007 Sep 7;424(2):127-32. Epub 2007 Aug 6. PubMed PMID:
17714869.
31: Keller TA, Kana RK, Just MA. A developmental study of the structural
integrity of white matter in autism. Neuroreport. 2007 Jan 8;18(1):23-7. PubMed
PMID: 17259855.
*
Original Research
Diffusion tensor fractional anisotropy of the normal-appearing seven segments of the corpus callosum in healthy adults and relapsing-remitting multiple sclerosis patients†
Article first published online: 19 MAY 2005
DOI: 10.1002/jmri.20296
Copyright © 2005 Wiley-Liss, Inc.
Additional Information(Show All)
How to Cite
Hasan, K. M., Gupta, R. K., Santos, R. M., Wolinsky, J. S. and
Narayana, P. A. (2005), Diffusion tensor fractional anisotropy of the
normal-appearing seven segments of the corpus callosum in healthy adults and
relapsing-remitting multiple sclerosis patients. J. Magn. Reson. Imaging,
21: 735–743. doi: 10.1002/jmri.20296
- †
Presented in part at the 12th Annual Meeting of ISMRM, Kyoto, Japan, 2004 (abstract 1498). The acquisition, processing, and quantitative analysis methodologies were also described in abstracts 338 and 1350 presented at the same meeting.
Publication History
- Issue published online: 19 MAY 2005
- Article first published online: 19 MAY 2005
- Manuscript Accepted: 7 FEB 2005
- Manuscript Received: 16 DEC 2004
Funded by
- NIH. Grant Numbers: R01 NS31499, R01 EB02095
- Dunn Research Foundation
- Department of Diagnostic and Interventional Imaging, University of Texas at Houston
- Abstract
- Article
- References
- Cited By
Keywords:
- diffusion tensor imaging;
- multiple sclerosis;
- corpus callosum
Abstract
Purpose
To investigate the utility of whole-brain diffusion tensor imaging (DTI) in
elucidating the pathogenesis of multiple sclerosis (MS) using the
normal-appearing white matter (NAWM) of the corpus callosum (CC) as a marker of
occult disease activity.
Materials and Methods
A high signal-to-noise ratio (SNR) and optimized entire brain DTI data were
acquired in 26 clinically-definite relapsing and remitting multiple sclerosis
(RRMS) patients and 32 age-matched healthy adult controls. The fractional
anisotropy (FA) values of seven functionally distinct regions in the
normal-appearing CC were compared between patients and controls.
Results
This study indicates that 1) there was a gender-independent FA heterogeneity
of the functionally specialized CC segments in normal volunteers; 2) FA in the
MS group was significantly decreased in the anterior (P = 0.0039) and
posterior (P = 0.0018) midbody subdivisions of the CC, possibly due to
a reduction of small-caliber axons; and 3) the FA of the genu of the CC was
relatively intact in the MS patients compared to the healthy age-matched
controls (P = 0.644), while the splenium showed an insignificant trend
of reduced FA values (P = 0.248). The decrease in FA in any of the CC
subdivisions did not correlate with disease duration (DD) or the expanded
disability status scale (EDSS) score.
Conclusion
The preliminary results are consistent with published histopathology and
clinical studies on MS, but not with some published DTI reports. This study
provides insights into the pathogenesis of MS, and the role played by
compromised axonal integrity in this disease. J. Magn. Reson. Imaging
2005;21:735–743. © 2005 Wiley-Liss, Inc.
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CME > AJP CME >
June 01, 2012
AJP CME Course for June 2012: Differences in White Matter Fiber Tract Development Present From 6 to 24 Months in Infants with Autism
Expires May 31, 2014
Estimates of the fractional anisotropy slope parameters with standard errors are presented for the ASD-positive and -negative groups for all tracts in Table 2. Both groups showed significant increases in fractional anisotropy from 6 to 24 months, though the rate of change for the ASD-negative group was significantly greater than that for the ASD-positive group in the bilateral limbic (fornix) and association (inferior longitudinal fasciculus and uncinate) fiber tracts. Individual and mean group trajectories for these tracts are presented in Figure 1. The changes from 6 to 24 months in fractional anisotropy for the corpus callosum subdivisions are shown in Figure 2; the change for the body was significantly different in the two groups. For projection tracts, the growth trajectories of the left anterior thalamic radiation and all internal capsule divisions were significantly steeper for the ASD-negative infants (Figure 3).
________________________________________
CME > AJP CME >
June 01, 2012
AJP CME Course for June 2012: Differences in White Matter Fiber Tract Development Present From 6 to 24 Months in Infants with Autism
Expires May 31, 2014
Fractional anisotropy values may be generated for white matter fiber tracts. Values in the high range (e.g., 0.8–1.0) are indicative of what quality?
A. Isotropic diffusion
B. Transverse diffusion
C. Weak directional diffusion
D. Strong directional diffusion
2.
At 6 months old, cross-sectional fractional anisotropy values for autism spectrum disorder (ASD)-negative and ASD-positive groups differed for which of the following white matter tracts?
A. Right uncinate fasciculus
B. Left inferior longitudinal fasciculus
C. Left anterior thalamic radiation
D. Splenium of corpus callosum
3.
In typical white matter development during infancy, what two processes combine to ensure efficient structural connectivity between brain regions?
A. Axon pruning and myelination
B. Apoptosis and glial cell proliferation
C. Neural refinement and canalization
D. Microglial activation and synaptogenesis
_______________________________________
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